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泽溪源专业提供定制的化学合成多肽合成,以及抗体定制服务和产品,以支持当地及世界各地学术院校、政府研究机构、制药和生物技术公司的生物研究,促进其不断向前发展。经由泽溪源提供的多肽合成及抗体服务,众多科学家在蛋白质组学和细胞生物学等领域均取得了许多创新性突破与发展。

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使用过泽溪源多肽和抗体服务的部分文献

Nature, Accepted 06 May 2014, doi:10.1038/nature13452, Carbonic anhydrases, EPF2 and a novel protease mediate CO2 control of stomatal development
Nature Materials, Accepted 14 April 2014, doi:10.1038/nmat3982, Etchable plasmonic nanoparticle probes to image and quantify cellular internalization
Nature Communications, 5, Article number: 3571 doi:10.1038/ncomms4571, An alternate binding site for PPARγ ligands
Nature, 497, 383–387, 2013, doi:10.1038/nature12080, EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2
Nature Communications, doi:10.1038/ncomms3261, Aug, 2013, Disrupting malaria parasite AMA1–RON2 interaction with a small molecule prevents erythrocyte invasion
Biochemistry, 2013, DOI: 10.1021/bi401034q, Mechanistic Basis for the Potent Anti-angiogenic Activity of Semaphorin 3F
PNAS, 2012, doi:10.1073/pnas.1119073109, Structures of KIX domain of CBP in complex with two FOXO3a transactivation domains reveal promiscuity and plasticity in coactivator recruitment
Cell, 2012, Volume 151, Issue 6, 1243-1255, Piwi-Interacting RNAs Protect DNA against Loss during Oxytricha Genome Rearrangement
Nature Immunology, 2011, doi:10.1038/ni.2107, The carboxypeptidase ACE shapes the MHC class I peptide repertoire
Journal of Virology, 2013, doi: 10.1128/JVI.00814-13, Cross-inhibition of ChikunGunya virus fusion and infection by alphavirus E1 domain III proteins

Srinivasan, P. et al. Disrupting malaria parasite AMA1–RON2 interaction with a small molecule prevents erythrocyte invasion. Nat. Commun. 4:2261 doi: 10.1038/ncomms3261 (2013).

Biotin-RON2, a synthetic biotinylated 42 mer peptide, was synthesized by LifeTein. Synthetic peptides are crucial in the process of understanding protein-protein interactions. Using a high throughput screen method, Prakash Srinivasan assessed the inhibitors that block interactions between AMA1-RON2. He shows that the inhibitor binds to AMA1 and prevents its interaction with RON2. Such inhibitors of merozoite invasion used in combination with existing antimalarials hold great promise as a novel therapeutic approach in the fight against malaria.

... Biotin-tagged RON2 peptide(DITQQAKDIGAGPVASCFTTRMSPPQQICLNSVVNTALSTSTQSAMK) with the two cysteines cyclized was synthesized and purified (95% pure) by LifeTein, LLC USA (New Jersey, USA) ...

ET Smith, DA Johnson, Protein Science, 2013, Human enteropeptidase light chain: Bioengineering of recombinants and kinetic investigations of Structure and function, DOI: 10.1002/pro.2239

Synthetic peptides by LifeTein were used as substrate to study the protein structure and function. ET Smith and DA Johnson found that the positively charged peptides could contribute the substrate specificity in human enteropeptidase. It shows importance of the charge-charge interactions in the substrate binding pocket. For example, peptide DDDDK and DDDDR could have different specificities for substrates.

... The extended peptide substrates GD4K-pNA and GD4R-pNA (LifeTein) were used at concentrations between 0.02-1.0 mM and 5-100 µM, respectively. Reactions were initiated by adding enzyme to ...

Paul M. Arnaboldi, et al. An outer surface protein C (OspC) peptide derived from Borrelia burgdorferi sensu strico as a target for the serodiagnosis of early Lyme disease, Published ahead of print 30 January 2013, doi: 10.1128/CVI.00608-12

LifeTein advanced the research on serodiagnostic assays for Lyme disease. The linear epitopes OspC1 was synthesized by LifeTein. This highly conserved 20 amino acid peptide epitope detected specific IgM and/or IgG in 60 out of 98 serum samples. This OspC1 peptide could have value as a component of a multi-peptide Lyme disease serological assay with significantly improved capabilities for the diagnosis of early infection. OspC1 was proved to have higher specificity than the commercial available OspC peptide.

... A positive signal was required to be at least 4x the FSI of the negative assay control. Peptides chosen for further analysis were produced by Lifetein, Inc. (South Plainfield, NJ), and were a minimum of 90% purity. ...